LGD-6972|cas 1207989-09-0

LGD-6972|cas 1207989-09-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: LGD-6972|Cas Number: 1207989-09-0| Catalog Number: DC10278|Other Nmaes: LGD6972; LGD 6972

LGD-6972 is a glucagon receptor antagonist.

LGD-6972 has linear plasma pharmacokinetics consistent with once daily dosing that is comparable in healthy and T2DM subjects. Dose-dependent decreases in fasting plasma glucose are observed in all groups with a maximum of 3.15 mM (56.8 mg/dL) on day 14 in T2DM subjects. LGD-6972 also reduces plasma glucose in the postprandial state. Dose-dependent increases in fasting plasma glucagon are observed, but glucagon levels decrease and insulin levels increase after an oral glucose load in T2DM subjects. LGD-6972 is well tolerated at the doses tested without dose-related or clinically meaningful changes in clinical laboratory parameters. No subject experiences hypoglycaemia[1].