WEHI-345|WEHI345|RIPK2 inhibitor

WEHI-345|WEHI345|RIPK2 inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: WEHI-345|Cas Number: 1354825-58-3| Catalog Number: DC10373|Other Nmaes: WEHI345，WEHI 345

WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM.

WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 μM. IC50 value: 0.13 μM Target: RIPK2 in vitro: WEHI-345 is a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement. WEHI-345 is an ATP analogue and was therefore predicted to bind in the ATP-binding pocket of RIPK2. WEHI-345 proved to be highly specific for RIPK2(Kd=46 nM) and displayed negligible activity (>10 μM) against RIPK1, RIPK4 and RIPK5. in vivo: WEHI-345 inhibits NOD signalling and has a beneficial effect on an EAE model. WEHI-345 blocks MDP-induced cytokine production. WEHI-345 ameliorates experimental autoimmune encephalomyelitis in mice. WEHI-345 also potently inhibited MDP-induced cytokine and chemokine secretion in the mouse macrophage Raw 264.7 cell line.