AS1842856|AS-1842856｜Foxo1 inhibitor

AS1842856|AS-1842856｜Foxo1 inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: AS1842856|Cas Number: 836620-48-5| Catalog Number: DC10086|Other Nmaes: AS 1842856，AS-1842856

AS1842856 is a potent and cell-permeable Foxo1 inhibitor with an IC50 of 30 nM.

AS1842856 is a potent and cell-permeable Foxo1 inhibitor with an IC50 of 30 nM.
InVitro: AS1842856 potently inhibits human Foxo1 transactivation and reduces glucose production through the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line.
InVivo: Oral administration of AS1842856 to diabetic db/db mice leads to a drastic decrease in fasting plasma glucose level via the inhibition of hepatic gluconeogenic genes, whereas administration to normal mice has no effect on the fasting plasma glucose level. Treatment with AS1842856 also suppresses an increase in plasma glucose level caused by pyruvate injection in both normal and db/db mice.