MBP146-78|cas 188343-77-3

MBP146-78|cas 188343-77-3

DC Chemicals, Website: www.dcchemicals.com

Product Name: MBP146-78|Cas Number: 188343-77-3| Catalog Number: DC10062|Other Nmaes: MBP146-78,MBP146-78

MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo.

MBP146-78 inhibits the growth of Eimeria spp. both in vitro and in vivo. The molecular target of MBP146-78 was identified as cGMP-dependent protein kinase (PKG) using a tritiated analogue to purify a approximately 120-kDa protein from lysates of Eimeria tenella. This represents the first example of a protozoal PKG.

MBP146-78 is a potent inhibitor of both soluble and membrane-associated isoforms of native PKG, as well as recombinant enzyme, with an IC(50) of <1 nm.