T0901317|T-0901317|LXR agonist

T0901317|T-0901317|LXR agonist.

T0901317 in stock, price: 300USD/100mg. T0901317 is a potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively).

Product Name: T0901317 |cas: 293754-55-9 |cat number: DC9842 |Molecule Formular: C17H12F9NO3S |MW: 481.33 |purity>98%

Potent, high affinity liver X receptor (LXR) agonist (EC50 ~ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ~ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).

For research only, not for human use.