BMS-779788(XL652)|LXR agonist

BMS-779788(XL652)|LXR agonist

BMS-779788(XL652) is a novel small-molecule modulator of the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders.

Product Name: BMS-779788(XL-652) |cas: 918348-67-1 |cat number: DC9861 |Molecule Formular: C28H29ClN2O3S  |MW: 508.15 |purity>98%

BMS-779788, also known as XL-652, EXEL 04286652 and BMS-788, is potent partial LXR agonist with LXRβ selectivity, which has an improved therapeutic window in the cynomolgus monkey compared with a full pan agonist. BMS-779788 induced LXR target genes in blood in vivo with an EC50 = 610 nM, a value similar to its in vitro blood gene induction potency. BMS-779788 was 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B.

For research and scientific purpose only, not for human use.