GK921|GK-921|TGase 2 inhibitor

GK921|GK-921|TGase 2 inhibitor

GK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 uM in cancer cell lines.

Product Name: GK921 |cas: 1025015-40-0 |cat number: DC9855 |Molecule Formular: C21H20N4O |MW: 344.41 |purity>98%

GK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 uM in cancer cell lines.
GK921 inhibited the tgase 2-induced polymerization of I-κBα and p53 in vitro in a dose-dependent manner. Oral administration of GK921 (8 mg/kg) began when tumors reached a volume of 100 mm3 and proceeded for 5 days/week. after 64 days of treatment, tumor volumes were significantly different in GK921-treated mice and vehicle-treated controls.

For research and scientific purpose only, not for human use.