AKR1C3 Inhibitor 5f|cas 1275482-57-9

AKR1C3 Inhibitor 5f|cas 1275482-57-9

A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3.

Product Name: AKR1C3 Inhibitor 5f |cas: 1275482-57-9 |cat number: DC9843 |Molecule Formular: C14H13NO3 |MW: 243.26 |purity>98%

A cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 2.65µM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 2.65µM, 84.4µM, for AKR1C3, AKR1C2, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells.

For research only, not for human use.