NVP-BAW2881,NVP-BAW 2881|VEGFR inhibitor

NVP-BAW2881,NVP-BAW 2881|VEGFR inhibitor

NVP-BAW2881 is a novel vascular endothelial growth factor (VEGF) receptor tyrosine-kinase inhibitor

Product name: NVP-BAW2881|Purity>98%| CAS: 861875-60-7 |Molecule Formular: C22H15F3N4O2 |MW: 424.11|Other Namess: NVP-BAW2881,NVP-BAW-2881,,NVP-BAW 2881

BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation. NVP-BAW2881 inhibited proliferation, migration, and tube formation by human umbilical vein endothelial cells and lymphatic endothelial cells in vitro. NVP-BAW2881 reduced the number of blood and lymphatic vessels and infiltrating leukocytes in the skin, and normalized the epidermal architecture. NVP-BAW2881 also displayed strong anti-inflammatory effects in models of acute inflammation; pretreatment with topical NVP-BAW2881 significantly inhibited VEGF-A-induced vascular permeability in the skin of pigs and mice.

For research only, not for human use.