ML-264,ML264|KLF5 inhibitor

ML-264,ML264|KLF5 inhibitor

ML264 is a novel small molecule inhibitor of Krüppel-like factor 5 (KLF5).

Product name: ML-264|Purity>98%| CAS: 1550008-55-3|Molecule Formular: C17H21ClN2O4S|MW: 384.87|Other Namess: ML-264; ML264; ML 264; CID-51003603

ML-264 is a Krüppel-like factor 5 (KLF5) inhibitor That Potently Inhibits Growth of Colorectal Cancer. ML264 is highly active (IC50 = 29 nM is a cell-based assay for proliferation of DLD-1 cells, IC50 = 81 nM in a cell-based luciferase assay). It lacks cytotoxicity in the IEC-6 control cell line (IC50 >50 μM, <50% inhibition was observed at 100 μM). Robust activity was also seen in several other KLF5-expressing cell types as well (e.g., HCT116, IC50 = 560 nM; HT29, IC50 = 130 nM; SW620, IC50 = 430 nM). ML264 is a good candidate for in vivo anticancer studies, with great potential for use in long time-course in situ studies aimed to elucidate the role of KLF5 as a regulator of cellular proliferation and tumor formation in the intestinal epithelium.

For research only, not for human use.