BTZ043|BTZ 043|DprE1 inhibitor|DC Chemicals

BTZ043|BTZ 043|DprE1 inhibitor|DC Chemicals

BTZ043 is a inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), It can display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

Product name: BTZ043|Purity>98%| CAS: 1161233-85-7|Molecule Formular: C17H16F3N3O5S|MW: 431.39|Other Namess: BTZ043,BTZ-043,BTZ 043

BTZ043 is a inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), It can display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
in vitro: The inhibition of BTZ-resistant DprE1 followed the trend observed in the MIC measurements, with the C387G mutant being more resistant to inhibition by PyrBTZ01, PyrBTZ02, and BTZ043 (7- to 9-fold increases in IC50) than the C387S mutant (2.5- to 4-fold increases in IC50).
in vivo: BTZ-043 were administered at 100 mg/kg twice daily by gavage, and sulfamethoxazole/trimethoprim (SXT), at 100 mg/kg sulfamethoxazole, was used as a positive control.

For research only, not for human use.