2016年7月14日星期四

EL102|EL-102|CAS 1233948-61-2

EL102|EL-102|CAS 1233948-61-2

EL-102 is a dual-inhibitor of apoptosis and angiogenesis, and exerts its action though the inhibition of Hif1 alpha induced hypoxic signalling pathways and induction of the Caspase 3/7 apoptotic cascade.

Product name: EL102|Purity>98%| CAS: 1233948-61-2|Molecule Formular: C19H16N2O3S2|MW: 384.47|Other Namess: EL-102, EL 102


EL102 is a novel toluidine sulphonamide, was developed from a phenotypic screen to develop novel small molecule inhibitors of the hypoxia signalling cascade. It is a dual-inhibitor of apoptosis and angiogenesis, and exerts its action though the inhibition of Hif1 alpha induced hypoxic signalling pathways and induction of the Caspase 3/7 apoptotic cascade. The drug has equal activity against normoxic and hypoxic tumour cells indicating that it may be equally active in these different tumour compartments.

For research only, not for human use.

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