UK-371804|UK-371804|uPA inhibitor

UK-371804|UK-371804|uPA inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: UK-371804 HCl|Cas Number: 256476-36-5| Catalog Number: DC10084|Other Nmaes: UK371804,UK 371804

UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). In vitro, UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. UK-371804 was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers.