SB290157 trifluoroacetate|cas 1140525-25-2
DC Chemicals, Website: www.dcchemicals.com
Product Name: SB290157 trifluoroacetate|Cas Number: 1140525-25-2| Catalog Number: DC10151|Other Nmaes: SB 290157 trifluoroacetate; SB-290157 trifluoroacetate
SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM.
SB 290157, inhibits neutrophil recruitment in a guinea pig LPS-induced airway neutrophilia model and decreases paw edema in a rat adjuvant-induced arthritis model[1]. The antagonist is able to reduce joint swelling only at 3 h, and about 50% inhibition of joint swelling is observed with the concentration of 30 mg/kg. The C3 level is significantly decreased at 3 h compared with naïve mice showing complement consumption. Furthermore, the C3 activation is observed and increased corresponding to the graded concentration of anti-OVA pAb[2].
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