R1487|R-1478|MAPK inhibitor

R1487|R-1478|MAPK inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: R1487|Cas Number: 449811-92-1| Catalog Number: DC10053|Other Nmaes: R-1487,R 1487

R1487 is a p38 MAP kinase inhibitor with an IC50 of 10nM. It may have potential as a treatment for inflammatory diseases such as rheumatoid arthritis.

The development of a new series of p38α inhibitors resulted in the identification of two clinical candidates, one of which was advanced into a phase 2 clinical study  For rheumatoid arthritis. The original lead, an lck inhibitor that also potently inhibited p38α, was a screening hit from our kinase inhibitor library. This manuscript describes the optimization of the lead to p38-selective examples with good pharmacokinetic properties.[1]For the detailed information of R1487, the solubility of R1487 in water, the solubility of R1487 in DMSO, the solubility of R1487 in PBS buffer, the animal experiment (test) of  R1487, the cell expriment (test) of R1487, the in vivo, in vitro and clinical trial test of R1487, the EC50, IC50,and Affinity of R1487, Please contact DC Chemicals.