ONO4059 analog|ONO-4059
DC Chemicals, Website: www.dcchemicals.com
Product Name: ONO4059 analog|Cas Number: 1351635-67-0| Catalog Number: DC10044|Other Nmaes: ON 0459 analog,ON-0459 analog
The product is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with an IC50 in the sub-nM range.
ONO-4059 is a highly selective, orally bioavailable BTK inhibitor with a potency (IC50) of 2.2 nM.
In vitro: The compound covalently bonds to BTK, inhibiting BCR signaling and B-cell proliferation and activation. NO/GS-4059 induced durable responses in relapsed/refractory B-cell malignancies without significant toxicities.
In vivo: ONO-4059 demonstrated therapeutic efficacy in a mouse arthritis model, and based on its anti-proliferative activity in B-cells.
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