JD5037|JD 5037|CB1 receptors agonist

JD5037|JD 5037|CB1 receptors agonist

DC Chemicals, Website: www.dcchemicals.com

Product Name: JD5037|Cas Number: 1392116-14-1| Catalog Number: DC10095|Other Nmaes: JD 5037,JD-5037

JD5037 is an inverse agonist of peripheral cannabinoid 1 (CB1) receptors (Ki = 0.35 nM).

JD5037 is an inverse agonist of peripheral cannabinoid 1 (CB1) receptors (Ki = 0.35 nM).It displays >700-fold selectivity for CB1 over CB2, >1,000-fold selectivity over a panel of 70 receptors, transporters, and ion channels, and low blood-brain barrier penetrance.JD5037 is orally bioavailable and reduces food intake, body weight, and hormonal/metabolic abnormalities in diet-induced obese mice.JD5037 reverses hyperphagia, reduces body weight, and improves metabolic parameters in Magel2-null mice, a model of Prader-Willi syndrome.