H3B-6527|H3B6527|FGFR4 inhibitor

H3B-6527|H3B6527|FGFR4 inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: H3B-6527|Cas Number: 1702259-66-2| Catalog Number: DC10033|Other Nmaes: H3B6527,H3B 6527

H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity.

H3B-6527 is an orally bioavailable inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity.  Upon administration, H3B-6527 specifically binds to and blocks FGFR4. This prevents the activation of FGFR4, inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. FGFR4, a receptor tyrosine kinase overexpressed by certain tumor cell types, is involved in tumor cell proliferation, differentiation, angiogenesis, and survival; FGFR4 expression is associated with poor prognosis.