CXCR2-IN-1 |cas 1873376-49-8

CXCR2-IN-1 |cas 1873376-49-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: CXCR2-IN-1|Cas Number: 1873376-49-8| Catalog Number: DC10203

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.

CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45)[1].CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis[1].