CFI-400437|CFI400437|PLK4 inhibitor
DC Chemicals, Website: www.dcchemicals.com
Product Name: CFI-400437|Cas Number: 1247000-76-5| Catalog Number: DC10069|Other Nmaes: CFI 400437,CFI400437
CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM).
CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468, and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth.
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