BBT594|cas 882405-89-2

BBT594|cas 882405-89-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: BBT594|Cas Number: 882405-89-2| Catalog Number: DC10058|Other Nmaes: BBT 594,BBT 594

BBT594 (NVP-BBT594), is potent and selective inhibitor of RET and JAK2.

BBT594 (NVP-BBT594), is potent and selective inhibitor of RET and JAK2. BBT594 impairs "glial-derived neurotrophic factor" (GDNF)-RET signalling and GDNF-dependent growth of in specific in vitro models. Direct inhibition of GDNF-RET signaling by BBT594 in ER+ breast cancer cells enhances the sensitivity to aromatase inhibitor (AI) treatment and reverts AI resistance. In murine models, the IC50 of BBT594 on JAK2 inhibition varies between 8nM - 29nM, depending on cell model and JAK2 mutation present.