Batefenterol(GSK961081,TD5959)|Muscarinic Antagonist/β2-Agonist
DC Chemicals, Website: www.dcchemicals.com
Product Name: Batefenterol(GSK961081)|Cas Number: 743461-65-6| Catalog Number: DC10021|Other Nmaes: GSK961081; GSK-961081; GSK 961081; TD-5959; TD 5959; TD5959; Batefenterol
Batefenterol(GSK961081,TD-5959)is a Muscarinic Antagonist and β2-Agonist possessing both muscarinic antagonist (MA) and β2-adrenoceptor agonist (BA) properties (MABA).
Batefenterol, also known as GSK961081 and TD-5959, is a Muscarinic Antagonist and β2-Agonist possessing both muscarinic antagonist (MA) and β2-adrenoceptor agonist (BA) properties (MABA). GSK-961081 displayed high affinity for hM2 (Ki = 1.4 nM), hM3 muscarinic receptors (Ki = 1.3 nM) and hβ2-adrenoceptors (Ki = 3.7 nM). GSK-961081 behaved as a potent hβ2-adrenoceptor agonist (EC50 = 0.29 nM for stimulation of cAMP levels) with 440- and 320-fold functional selectivity over hβ1- and hβ3-adrenoceptors, respectively.
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