Aldoxorubicin?HCl|cas 1361563-03-2| DC Chem|Supplier|Price|Buy 

Aldoxorubicin?HCl|cas 1361563-03-2| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Aldoxorubicin?HCl, Cas: 1361563-03-2 ,Cat No. DC7355, Purity>98%, In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642470；

Aldoxorubicin?HCl|cas 1361563-03-2, Synonym name: Aldoxorubicin HCl, CHEMBL2107827, 1361563-03-2, D10384, Chemical name:　N-[(E)-[1-[(2S,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-hydroxyethylidene]amino]-6-(2,5-dioxopyrrol-1-yl)hexanamide;hydrochloride, Molecule weight: 787.20932, Molecule Formula: C37H43ClN4O13

Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA. 

Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA. Aldoxorubicin, also known as INNO-206,  is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Following intravenous administration, doxorubicin prodrug INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hyervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity.