ABT-333|cas 1132935-63-7| DC Chem|Supplier|Price|Buy 

ABT-333|cas 1132935-63-7| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: ABT-333, Cas: 1132935-63-7 ,Cat No. DC7352, Purity>98%, In stock.

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ABT-333|cas 1132935-63-7, Synonym name: ABT333; ABT 333, Chemical name:　N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide, Molecule weight: 493.57, Molecule Formula: C26H27N3O5S

ABT-333 is an NS5B non-nucleoside polymerase inhibitor.

ABT-333 is an NS5B non-nucleoside polymerase inhibitor.

IC50 value:

Target: HCV NS5B

in vitro:

in vivo: All patients received ABT-333 (400 mg twice daily) and ribavirin (1000 to 1200 mg per day) and one of two daily doses of ABT-450/r. Groups 1 and 2 included previously untreated patients; group 1 received 250 mg of ABT-450 and 100 mg of ritonavir, and group 2 received 150 mg and 100 mg, respectively. Group 3, which included patients who had had a null or partial response to previous therapy with peginterferon and ribavirin, received daily doses of 150 mg of ABT-450 and 100 mg of ritonavir [1]. An interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r), the nonnucleoside polymerase inhibitor ABT-333, and ribavirin showed efficacy against the hepatitis C virus (HCV) in a pilot study involving patients with HCV genotype 1 infection [2].