AT13148|cas 1056901-62-2| DC Chem|Supplier|Price|Buy

AT13148|cas 1056901-62-2| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: AT13148, Cas: 1056901-62-2 ,Cat No. DC7362, Purity>98%, In stock.

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AT13148|cas 1056901-62-2, Synonym name: AT-13148,AT 13148, Chemical name:　(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol, Molecule weight: 313.78, Molecule Formula: C17H16ClN3O

AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals.  AT131148 was identified utilizing high-throughput X-ray crystallography and fragment-based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK substrate phosphorylation and induction of apoptosis in both a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects both in vitro and in vivo.