I-CBP112|CBP/p300 bromodomain inhibitor

I-CBP112|CBP/p300 bromodomain inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: I-CBP112|Cas Number: 1640282-31-0| Catalog Number: DC9982|Other Nmaes: I-CBP112; I-CBP-112; I-CBP 112

I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively).

I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively). I-CBP112 has little activity against other bromodomains at concentrations up to 1 mM. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.