JIB04|cas 199596-05-9| DC Chem|Supplier|Price|Buy  

JIB04|cas 199596-05-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: JIB04, Cas: 199596-05-9 ,Cat No. DC7437, Purity>98%, In stock.

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JIB04|cas 199596-05-9, Synonym name: NSC693627,JIB04; JIB 04, Chemical name:　5-Chloro-2-[(E)-2-[phenyl(pyridin-2?-yl)methylidene]hydrazin-1-yl]pyridine, Molecule weight: 308.76, Molecule Formula: C17H13ClN4

JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

JIB-04 induces transcriptional changes in a cancer-selective manner, including the downregulation of proliferative genes and the upregulation of the anti-proliferative/pro-apoptotic genes. JIB-04 blocks growth of lung and prostate cancer lines with IC50 as low as 10 nM, while produces less anti-proliferative activities on HBECs and PrSCs/PrECs. [1] In two separate xenograft mouse models (H358 or A549), JIB-04 diminishes tumor growth, lowers Jumonji histone demethylase activity in tumors, and prolongs cancer survival. [1]