JAK2 Inhibitor V|cas 195371-52-9| DC Chem|Supplier|Price|Buy  

JAK2 Inhibitor V|cas 195371-52-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: JAK2 Inhibitor V, Cas: 195371-52-9 ,Cat No. DC7436, Purity>98%, In stock.

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JAK2 Inhibitor V|cas 195371-52-9, Synonym name: Z3; NSC 42834; 1-Butanone, 2-methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-, Chemical name:　, Molecule weight: 344.5, Molecule Formula: C23H24N2O

Z3(NSC 42834), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.

JAK2 Inhibitor V, Z3 is a cell-permeable pyridinylbutanone compound that inhibits both JAK2 and the active V167F mutant cellular autophosphorylation. JAK2 Inhibitor V, Z3 displays no effect against cellular Tyk 2 autophosphorylation in COS cells or SRC in cell-free kinase assays. JAK2 Inhibitor V, Z3 suppresses the JAK2-V167F-dependent proliferation of the erythroleukemia cell line HEL by blocking the G1-S transition and is shown to effectively reduce the cytokine-stimulated growth of both Jak2-V617F-positive and Jak2-F537I-positive primary hematopoietic progenitor cells from myeloproliferative disorder patients.