J-147|cas 1146963-51-0| DC Chem|Supplier|Price|Buy  

J-147|cas 1146963-51-0| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: J-147, Cas: 1146963-51-0 ,Cat No. DC7435, Purity>98%, In stock.

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J-147|cas 1146963-51-0, Synonym name: , Chemical name:　1-?(2,?4-?dimethylphenyl)-?2-?[(3-?methoxyphenyl)methylene]hydrazide,? 2,?2,?2-?trifluoro-?acetic acid, Molecule weight: 350.3, Molecule Formula: C18H17F3N2O2

J 147, a hybrid of curcumin (Item No. 81025) and the neurotrophic compound, cyclohexyl-bisphenol A, displays broad neuroprotective activity (EC50 = 25 nM) in a panel of assays representing neurotoxicity pathways related to aging and neurodegenerative disease.1 J 147 has been shown to enhance memory in normal animals and to prevent memory deficits in an Alzheimer’s disease mouse model.1 These effects are associated with an increase in brain derived neurotrophic factor levels, enhanced long-term potentiation, preservation of synaptic proteins, a reduction of markers for oxidative stress and inflammation, a reduction of amyloid plaques, and lower levels of soluble amyloid β.1