IWP-L6|cas 1427782-89-5| DC Chem|Supplier|Price|Buy  

IWP-L6|cas 1427782-89-5| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: IWP-L6, Cas: 1427782-89-5 ,Cat No. DC7434, Purity>98%, In stock.

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IWP-L6|cas 1427782-89-5, Synonym name: Porcn Inhibitor III,IWP-L6, Chemical name:　N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide, Molecule weight: 472.58, Molecule Formula: C25H20N4O2S2

IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM.

IWP-L6 blocks the phosphorylation of the cytoplasmic Wnt pathway effector Dvl2 in HEK293 cells. In cultured embryonic kidneys, IWP-L6 also inhibits Wnt mediated branching morphogenesis by reversibly blocking Wnt signaling. [1] IWP-L6 is stable in human plasma over 24 h, while rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions. In embryonic zebrafish, IWP-L6 effectively inhibits posterior axis formation, a Wnt/β-catenin dependent developmental process. [1]