IWP-2-V2|cas 877618-79-6| DC Chem|Supplier|Price|Buy  

IWP-2-V2|cas 877618-79-6| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: IWP-2-V2, Cas: 877618-79-6 ,Cat No. DC7433, Purity>98%, In stock.

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IWP-2-V2|cas 877618-79-6, Synonym name: Inhibitor of Wnt Production-2-V2, Chemical name:　N-?(6-?methyl-?2-?benzothiazolyl)-?2-?[[3,?4,?6,?7-?tetrahydro-?4-?oxo-?3-?(phenylmethyl)thieno[3,?2-?d]pyrimidin-?2-?yl]thio]-?acetamide, Molecule weight: 480.6, Molecule Formula: C23H20N4O2S

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-2 (Item No. 13951) is an inhibitor of Wnt production (IC50 = 27 nM) that inactivates porcupine, a membrane-bound O-acyltransferase whose palmitoylation activity is essential for the signaling ability and secretion of Wnt proteins.4 IWP-2-V2 is a less potent IWP-2 derivative whose chemical structure retains the benzothiazole group of its parent compound.4 It has been used to determine which structural features of IWP-2 are essential for impairing Wnt/β-catenin pathway activity.4