JNJ-28312141|cas 885692-52-4| DC Chem|Supplier|Price|Buy  

JNJ-28312141|cas 885692-52-4| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: JNJ-28312141, Cas: 885692-52-4 ,Cat No. DC7438, Purity>98%, In stock.

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JNJ-28312141|cas 885692-52-4, Synonym name: JNJ-28312141; JNJ28312141; JNJ 28312141., Chemical name:　4-cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carboxamide, Molecule weight:  460.57, Molecule Formula: C26H32N6O2

JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.