BMS-303141|cas 943962-47-8| DC Chem|Supplier|Price|Buy

BMS-303141|cas 943962-47-8| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: BMS-303141, Cas: 943962-47-8 ,Cat No. DC7375, Purity>98%, In stock.

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BMS-303141|cas 943962-47-8, Synonym name: BMS303141; BMS 303141, Chemical name:　, Molecule weight: 424.3, Molecule Formula: C19H15Cl2NO4S

BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor with IC50 value of 0.13 uM (human recombinant ACL).

BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor with IC50 value of 0.13 uM (human recombinant ACL).

IC50 value: 0.13 uM [1]

Target: ATP citrate lyase

in vitro: In HepG2 cells, BMS-303141 showed inhibition of total lipid syntheses with an IC50 of 8 μM. A cell based Alamar Blue cytotoxicity assay was used in parallel to differentiate the effect on the inhibition of lipid synthesis versus potential cytotoxicity. Under identical incubation conditions, BMS-303141 showed no cytotoxicity up to 50 μM, indicating the observed inhibition of lipid synthesis was not a result of compound-induced cytotoxicity [1].

in vivo: In mice, BMS-303141 showed an oral bioavailability of 55% but a relatively short half-life of 2.1 h.20 We therefore decided to dose BMS-303141 admixed in the food to assure greater duration of exposure in subsequent chronic efficacy studies.There were a total of four groups in the study; mice on normal diet and high-fat diet controls, and two treated groups that were supplemented with BMS-303141 in their high-fat diet to an equivalent daily dose of 10 or 100 mg/kg. The study was continued for a total of 34 days. Food consumption and body weight gain were tracked along with weekly assessment of lipid and glucose plasma chemistries [1].