BIX01294|cas 1392399-03-9| DC Chem|Supplier|Price|Buy 

BIX01294|cas 1392399-03-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: BIX01294, Cas: 1392399-03-9 ,Cat No. DC7374, Purity>98%, In stock.

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BIX01294|cas 1392399-03-9, Synonym name: BIX 01294; BIX01294, Chemical name:　4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-, hydrochloride (1:3), Molecule weight: 600.02, Molecule Formula: C28H38N6O2.3HCl

BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM.

BIX01294 is a selective inhibitor of G9a histone methyltransferase and does not affect SUV39H1(H320R) and PRMT1 within the tested concentration range. BIX-01294 specifically inhibited G9a (H3K9me2) and, to a lesser extent, the closely related GLP enzyme (primarily H3K9me3), with an IC50 of 1.7 μM for G9a and 38 μM for GLP. BIX-01294 inhibits G9a in an uncompetitive manner with SAM. BIX-01294 (4.1μM) reduces H3K9me2 Levels in Bulk Histone Preparations from wt ES cells, mouse embryonic fibroblasts and HeLa cells, but not in G9a deficient stem cells. BIX-01294 is a valuable inhibitor for the transient modulation of chromosomal H3K9me2. BIX-01294 Reduces H3K9me2 at Several G9a Target Genes including Bim1 and Serac1. [1] BIX01294 could reactivate expression of HIV-1 from latently infected cells such as ACH-2 and OM10.1. [2]