BMS777607|cas 1196681-44-3| DC Chem|Supplier|Price|Buy 

BMS777607|cas 1196681-44-3| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: BMS777607, Cas: 1196681-44-3 ,Cat No. DC7376, Purity>98%, In stock.

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BMS777607|cas 1196681-44-3, Synonym name: BMS777607; BMS-777607, Chemical name:　N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide, Molecule weight: 512.892566, Molecule Formula: C25H19ClF2N4O4

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other

BMS-777607, a Met tyrosine kinase inhibitor, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.