FLI-06|cas 313967-18-9| DC Chem|Supplier|Price|Buy 

FLI-06|cas 313967-18-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: FLI-06, Cas: 313967-18-9 ,Cat No. DC7415, Purity>98%, In stock.

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FLI-06|cas 313967-18-9, Synonym name: , Chemical name:　cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, Molecule weight: 438.52, Molecule Formula: C25H30N2O5

FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 μM), identified by using automated microscopy to monitor the trafficking and processing of a ligand-independent Notch-GFP fusion

In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER. [1] FLI-06 (50 μM) inhibits endogenous Notch signaling in zebrafish embryos. [1]