FH535|cas 108409-83-2| DC Chem|Supplier|Price|Buy

FH535|cas 108409-83-2| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: FH535, Cas: 108409-83-2 ,Cat No. DC7414, Purity>98%, In stock.

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FH535|cas 108409-83-2, Synonym name: FH 535; FH-535, Chemical name:　, Molecule weight: 361.2, Molecule Formula: C13H10Cl2N2O4S

FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.

IC50 Value: 1.1uM (Cytotoxicity in the CCLP-1 cell line) [1]

 FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. FH535antagonizes both PPAR gamma and PPAR delta ligand-dependent activation and shows structural similarity to GW9662, a known PPAR gamma antagonist.

in vitro: FH535 significantly inhibited cell migration of Mel 1241 cells, which was associated with the elevated levels of casein kinase 1α and glycogen synthase kinase-3β, and decreased accumulation of nuclear β-catenin and inhibition of MMP-2 and MMP-9 levels [2]. FH535 was shown to increase CSC-induced cytotoxicity and depress β-catenin expression. However, FH535 effects were not limited to the β-catenin pathway as it also blocked the expression of early growth responsive protein 1 (EGR-1) target genes, fibronectin and phosphatase and tensin homologue, without affecting EGR-1 nuclear accumulation [3]. Western blotting analyses suggest that treatment of MDA-MB-231 cells with FH535 markedly inhibited the expression of NEDD9 but not activations of FAK, Src, or downstream targets such as p38 and Erk1/2 [4].