KU14R|cas 189224-48-4| DC Chem|Supplier|Price|Buy 

KU14R|cas 189224-48-4| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: KU14R, Cas: 189224-48-4 ,Cat No. DC7447, Purity>98%, In stock.

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KU14R|cas 189224-48-4, Synonym name: KU-14R; KU 14R, Chemical name:　, Molecule weight: 214.26, Molecule Formula: C13H14N2O

KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.

A new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by measuring KATP channel activity, plasma membrane potential, cytosolic calcium concentration ([Ca2+]c) and dynamic insulin secretion. In the presence of 10 mmol/l but not of 5 mmol/l glucose, KU14R (30, 100 or 300 micromol/l) was ineffective. KATP channel was blocked by KU14R (IC50 31.9 micromol/l, Hill slope -1.5). KU14R does not act as an antagonist of either efaroxan or S22068 at an imidazoline site in vivo.