KN-92-hydrochloride|cas 1431698-47-3| DC Chem|Supplier|Price|Buy 

KN-92-hydrochloride|cas 1431698-47-3| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: KN-92-hydrochloride, Cas: 1431698-47-3 ,Cat No. DC7441, Purity>98%, In stock.

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KN-92-hydrochloride|cas 1431698-47-3, Synonym name: KN 92 hydrochloride; KN92 hydrochloride, Chemical name:　, Molecule weight: 493.45, Molecule Formula: C24H26Cl2N2O3S

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).

KN-92 is an inactive derivative of KN-93. It is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell.