Inauhzin|cas 309271-94-1| DC Chem|Supplier|Price|Buy

Inauhzin|cas 309271-94-1| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Inauhzin, Cas: 309271-94-1 ,Cat No. DC7428, Purity>98%, In stock.

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Inauhzin|cas 309271-94-1, Synonym name: INZ, Chemical name:　, Molecule weight: 469.58, Molecule Formula: C25H19N5OS2

Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).

Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).

IC50 value: 3 uM(A549 cell); 5.4 uM (H460 cell) [1]

Target: SIRT1

in vitro: Inauhzin effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, INZ stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, INZ inhibits cell proliferation, induces senescence and tumour-specific apoptosis [1].

in vivo: represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice [1].