HS-173|cas 1276110-06-5| DC Chem|Supplier|Price|Buy  

HS-173|cas 1276110-06-5| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: HS-173, Cas: 1276110-06-5 ,Cat No. DC7426, Purity>98%, In stock.

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HS-173|cas 1276110-06-5, Synonym name: HS 173,HS173, Chemical name:　ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate, Molecule weight: 422.46, Molecule Formula: C21H18N4O4S

HS-173 is a potent PI3Kα inhibitor with IC50 of 0.8 nM.

HS-173 shows potent antiproliferative effects in T47D, SK-BR3, and MCF7 cells with IC50 of 0.6, 1.5, and 7.8 μM, respectively. [1] HS-173 causes complete suppression of the PI3K pathway in cancer cell lines (Hep3B and SkBr3). Moreover, HS-173 induces cell apoptosis by affecting cell-cycle distribution and activating caspases, and block VEGF-induced angiogenesis in vitro. [2] Combined treatment with Sorafenib and HS-173 has a synergistic anti-cancer effect on pancreatic cancer cells. [3] HS-173 diminishes blood vessel formation in mice. [2] HS-173 markedly attenuates the development of liver fibrosis by blocking PI3K/Akt signaling in vivo. [4]