GO 6976|cas 136194-77-9| DC Chem|Supplier|Price|Buy  

GO 6976|cas 136194-77-9| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: GO 6976, Cas: 136194-77-9 ,Cat No. DC7421, Purity>98%, In stock.

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GO 6976|cas 136194-77-9, Synonym name: GO-6976,GO6976, Chemical name:　5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, Molecule weight: 378.43, Molecule Formula: C24H18N4O

Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.