Genz-123346|cas 491833-30-8| DC Chem|Supplier|Price|Buy

Genz-123346|cas 491833-30-8| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Genz-123346, Cas: 491833-30-8 ,Cat No. DC7417, Purity>98%, In stock.

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Genz-123346|cas 491833-30-8, Synonym name: Genz-123346; Genz123346; Genz 123346, Chemical name:　N-[(1R,2R)-1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]nonanamide, Molecule weight: 418.57, Molecule Formula: C24H38N2O4

Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.