Erastin|cas 571203-78-6| DC Chem|Supplier|Price|Buy  

Erastin|cas 571203-78-6| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Erastin, Cas: 571203-78-6 ,Cat No. DC7410, Purity>98%, In stock.

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Erastin|cas 571203-78-6, Synonym name: , Chemical name:　4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-, Molecule weight: 547.04, Molecule Formula: C30H31ClN4O4

Erastin is a compound that interacts with VDAC, blocked and reversed mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers.

Erastin is selectively lethal to oncogenic RAS-mutant cell lines, and triggers a unique iron-dependent form of non-apoptotic cell death called ferroptosis. [1] [2] Erastin binds directly to VDAC2 and causes mitochondrial damage via ROS production in an NADH-dependent manner, which induces cell death in some tumor cells harbouring activating mutations in the RAS-RAF-MEK pathway. [3] In addition, erastin, via inducing ROS-mediated CID (Caspase-independent cell death), strongly enhances the effect of cisplatin in WT EGFR cells. [4]