EMD-1214063|cas 1100598-32-0| DC Chem|Supplier|Price|Buy

EMD-1214063|cas 1100598-32-0| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: EMD-1214063, Cas: 1100598-32-0 ,Cat No. DC7408, Purity>98%, In stock.

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sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

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EMD 1214063 is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer.

EMD-1214063 is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor EMD-1214063 selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated in many tumor cell types; this protein plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.