DY131|cas 95167-41-2| DC Chem|Supplier|Price|Buy  

DY131|cas 95167-41-2| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: DY131, Cas: 95167-41-2 ,Cat No. DC7405, Purity>98%, In stock

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DY131|cas 95167-41-2, Synonym name: GSK 9089; DY-131; DY 131; GSK9089; GSK-9089, Chemical name:　, Molecule weight: 311.38, Molecule Formula: C18H21N3O2

DY131(GSK 9089) is a novel selective agonist of ERRβ and ERRγ; displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.

DY131, a selective ERRγ agonist, could potentiate the ERRγ-induced growth inhibition in LNCaP- ERRγ and DU145- ERRγ cells in a dose-dependent manner compared with respective parental cells. DY131 inhibited the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells. DY131 had no effect on the structurally related receptors ERRα or the estrogen receptors alpha and beta (ERalpha/beta). DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists.