CUDC-305|cas 1061318-81-7| DC Chem|Supplier|Price|Buy 

CUDC-305|cas 1061318-81-7| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: CUDC-305, Cas: 1061318-81-7 ,Cat No. DC7390, Purity>98%, In stock.

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CUDC-305|cas 1061318-81-7, Synonym name: Debio-0932; CUDC-305., Chemical name:　2-((6-(dimethylamino)benzo[d][1,3]dioxol-5-yl)thio)-1-(2-(neopentylamino)ethyl)-1H-imidazo[4,5-c]pyridin-4-amine, Molecule weight: 442.5776, Molecule Formula: C22H30N6O2S

Debio 0932, also known as CUDC-305, is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance. Furthermore, Debio 0932 is able to extend animal survival in models of brain metastasis due to its ability to cross the blood-brain barrier, and it enhances the activity of several standard-of-care agents in animal models of cancer.