CK-636|cas 442632-72-6| DC Chem|Supplier|Price|Buy

CK-636|cas 442632-72-6| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: CK-636, Cas: 442632-72-6 ,Cat No. DC7386, Purity>98%, In stock.

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CK-636|cas 442632-72-6, Synonym name: CK636; CK 636; CK-0944636; CK0944636; CK 0944636, Chemical name:　N-?[2-?(2-?Methyl-?1H-?indol-?3-?yl)?ethyl]?-?2-?thiophenecarboxamide, Molecule weight: 284.38, Molecule Formula: C16H16N2OS

CK-636(CK-0944636) is a small molecule inhibitor of Arp2/3 complex; Inhibitor of actin polymerization; Cell permeable inhibitor of human (IC50=4μM), fission yeast (IC50=24μM) and bovine (IC50=32μM) Arp2/3 complex between Arp2 and Arp3. Inhibits actin poly

CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. [1] CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns. [2]