AZD-628|cas 878739-06-1| DC Chem|Supplier|Price|Buy

AZD-628|cas 878739-06-1| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: AZD-628, Cas: 878739-06-1 ,Cat No. DC7370, Purity>98%, In stock.

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AZD-628|cas 878739-06-1, Synonym name: AZD 628,AZD628, Chemical name:　3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide, Molecule weight: 451.52, Molecule Formula: C27H25N5O2

Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.