XL-228|cas 898280-07-4| DC Chem|Supplier|Price|Buy  

XL-228|cas 898280-07-4| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: XL-228|cas 898280-07-4,Purity: >98% ,Cat No. DC7043, In stock.

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XL-228|cas 898280-07-4 ,Synonym: XL-228; XL 228  ,Chemical name: 4-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine ,Molecular Formula: C22H31N9O ,MW:437.54124

XL-228, cas 898280-07-4,Purity: >98%, Best Price and quality from DC Chemicals. XL228 is a protein kinase inhibitor targeting IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.

A synthetic molecule that targets multiple tyrosine kinases with potential antineoplastic activity. Tyrosine kinase inhibitor XL228 binds to and inhibits the activities of multiple tyrosine kinases, such as the insulin-like growth factor 1 receptor (IGF1R), Src tyrosine kinase, and Bcr-Abl tyrosine kinase. Blockade of these kinases may result in the inhibition of tumor angiogenesis, cell proliferation, and metastasis. In addition, this agent may be a potent inhibitor of the T315I mutant form of the Abl protein, which is associated with the resistance of chronic myelogenous leukemia (CML) to other tyrosine kinase inhibitors.